<i>In Vitro antisickling</i> and Free Radical Scavenging Activities of <i>Kigelia africana</i> (LAM) Stem Bark

Kigelia africana dried bark has been recommended in the management of sickle cell anemia by traditional practitioners. The aim this study was to evaluate vitro antioxidant and sickling inhibitory activities africana. Quantitative estimation phenolic compounds performed using colorimetric method hydro-ethanolic extract (70%) decocted. activity determinate according Emmel evaluation properties carried out scavenging free radical DPPH. obtained results indicated that species contains flavonoids (8.61±1.08 mg QE 9.78±1.14 QE/g dry weight) total phenols (9.48±0.19b GAE/g 11.11±0.22 GAE /g decocted hydroethanolic respectively. IC50 values ethanolic were 0.320±0.01 0.468±0.04 mg/mL sickle-formation inhibition test value 89% 82.36% for at 10mg/mL Those higher than 80% which phenylalanine value. Both extracts showed activities. Overall, there could have a correlation between these compound content studied plant extracts. These would justify use rural environment.